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KMID : 0613319960020010027
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Journal of the Korean Bone and Joint Tumor Soceity
1996 Volume.2 No. 1 p.27 ~ p.32
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Clinical Results of Neo-Adjuvant Chemotherapy and Surgery on Osteosarcoma
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Kang Yong-Koo
Kim Hyoung-Min
Rhee Seung-Koo
Woo Young-Kyun
Kim Jung-Man
Kim Hoon-Kyo
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Abstract
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Recent advances in imaging techiques,surgery and combination anti-cancer chemotherapy have brought high survival rates in osteosarcoma. To investigate the survival rate,local recurrence and complications in treatment,we analysed 25 osteosarcoma cases who had been treated with preoperative neo-adjuvant chemotherapy,sugery and post operative chemotherapy at Department of Orthopedic Surgery, Catholic University. From May 1988 to April 1995,42 cases of stage IIB steosarcoma were admitted in Department of Orthopedic surgery.Anong them,17 cases who didn`t follow our treatment guidance were excluded in this study. The average age were 19years.There were 21 males and 4 females.The involved sites were 4 humerus,10 femur,10 tibia and 1 talus.Eleven cases had received intraarterial cisplatin and intra-venous adriamycin chemotherapy,and 7 T-10 protocol and 7 intravenous ifosfamide, ADR, methotrexate,cisplatin.Twenty-three cases were treated with limb salvage sugery,and 2 amputation. The average follow-up was 35 months(3~82). There were 14 cases of continuous disease free,9 cases of died of disease,1 case of alive with disease,and 1 case of no evidence of disease at final fol-low-up.There were three cases of local recurrence at 6,8 and 12 months after operation.The estimat-ed Kaplan-Meier`s 5 year survival rates for all,ADR-cisplatin group,T-10 protocol group,and ifos-famide regimen group were 66%,73%,44% and 72%,respectively.
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KEYWORD
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osteosarcoma, neo-adjuvant chemotherapy, survival
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